- The Cardinals are -4.5 point favorites vs the Panthers
- Total (Over/Under): 47 points
- Watch this game on FOX
The Arizona Cardinals (7-7-0) visit Bank of America Stadium to take on the Carolina Panthers (3-11-0) on Dec. 22. Kickoff is scheduled for 1:00pm EST in Charlotte, NC.
The Cardinals are betting favorites in this matchup, with the spread sitting at -4.5 (-110).
The Cardinals vs. Panthers Over/Under is 47 total points for the game.
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Cardinals vs. Panthers Odds, Spread, Over/Under
| Spread | Total (O/U) | Moneyline | |
| Cardinals | -4.5 -110 | 47 -110 | -225 |
| Panthers | +4.5 -110 | 47 -110 | +185 |
Cardinals vs. Panthers Prediction
The winning team model predicts the Cardinals will win this game with 57.0% confidence, based on game simulations, player injuries, offensive & defensive matchups and recent game results.
Cardinals vs Panthers Spread Prediction
Based on recent against-the-spread trends, the model predicts the Panthers will cover the spread with 56.0% confidence.
This prediction against the spread factors in ATS performances for both teams, opening and current betting lines plus public and sharp money already wagered on this matchup.
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We’ve highlighted some favorite NFL player prop bets for Cardinals players this playoff game, looking at profitable historical betting trends:
Best Cardinals Player Prop Bets Today
- Marvin Harrison Jr. has hit the Receptions Under in 11 of his last 14 games (+8.30 Units / 47% ROI)
- Kyler Murray has hit the Carries Under in 12 of his last 17 games (+7.00 Units / 34% ROI)
- James Conner has hit the Receptions Over in 11 of his last 17 games (+6.20 Units / 29% ROI)
- Chad Ryland has hit the Field Goals Over in 6 of his last 7 away games (+5.95 Units / 85% ROI)
- Marvin Harrison Jr. has hit the Receiving Yards Under in 8 of his last 11 games (+4.70 Units / 38% ROI)
And here are some top NFL player prop bets for Panthers players for this matchup, looking at profitable historical betting trends:
Best Panthers Player Prop Best Bets Today
- Miles Sanders has hit the Carries Under in 8 of his last 9 games (+7.10 Units / 64% ROI)
- Chuba Hubbard has hit the Receiving Yards Under in 11 of his last 17 games (+4.15 Units / 21% ROI)
- Chuba Hubbard has hit the Rushing Yards Over in 7 of his last 10 games at home (+3.45 Units / 30% ROI)
- Miles Sanders has hit the Rushing Yards Under in 8 of his last 12 games (+3.40 Units / 24% ROI)
- David Moore has hit the Receiving Yards Under in 7 of his last 10 games (+3.35 Units / 27% ROI)
First Touchdown Scorer Bet for Panthers vs Cardinals
| Player Name | 1st TD Odds |
|---|---|
| James Conner (Ari) | +280 |
| Chuba Hubbard (Car) | +360 |
| Marvin Harrison Jr. (ARI) | +800 |
Cardinals Best Bets:
- The Arizona Cardinals have hit the 3Q Moneyline in 10 of their last 17 games (+6.45 Units / 33% ROI)
- The Arizona Cardinals have covered the 3Q Spread in 12 of their last 17 games (+6.40 Units / 31% ROI)
- The Arizona Cardinals have covered the 2H Spread in 10 of their last 14 games (+6.23 Units / 39% ROI)
- The Arizona Cardinals have hit the 2H Moneyline in 9 of their last 13 games (+6.08 Units / 41% ROI)
- The Arizona Cardinals have hit the 4Q Moneyline in 9 of their last 17 games (+5.15 Units / 27% ROI)
Panthers Best Bets:
- The Carolina Panthers have hit the 2Q Game Total Over in 13 of their last 17 games (+8.90 Units / 48% ROI)
- The Carolina Panthers have hit the 1H Game Total Over in 13 of their last 19 games (+7.45 Units / 34% ROI)
- The Carolina Panthers have hit the 4Q Game Total Under in 12 of their last 17 games (+6.10 Units / 30% ROI)
- The Carolina Panthers have covered the 3Q Spread in 11 of their last 17 games (+4.35 Units / 21% ROI)
- The Carolina Panthers have hit the Game Total Over in 12 of their last 19 games (+4.30 Units / 21% ROI)
Cardinals Against the Spread (ATS) Record
Against the spread this NFL season, the Cardinals art 9-5 (+3.3 Units / 21.02% ROI).
- Cardinals are 7-7 when betting on the Moneyline for +1.2 Units / 6.76% ROI
- Cardinals are 6-7 when betting the Over for -1.7 Units / -11.04% ROI
- Cardinals are 7-6 when betting the Under for +0.4 Units / ROI
Panthers Against the Spread (ATS) Record
Against the spread this NFL season, the Panthers are 6-8 (-2.8 Units / -18.3% ROI).
- Panthers are 3-11 when betting on the Moneyline for -4.05 Units / -28.13% ROI
- Panthers are 10-4 when betting the Over for +5.6 Units / 36.36% ROI
- Panthers are 4-10 when betting the Under for -7 Units / -45.45% ROI
Arizona Cardinals: Keys to the Game vs. the Carolina Panthers
The Cardinals were winless (0-3) when forcing 2 or more turnovers last season — worst in NFL; League Avg: .707.
The Cardinals were winless (0-5) when allowing 250 or more passing yards last season — T-worst in NFL; League Avg: .414.
The Cardinals were 1-6 (.143) when sacking the QB 3 or more times last season — 2nd-worst in NFL; League Avg: .650.
The Cardinals were winless (0-10) when scoring less than 22 points last season — T-worst in NFL; League Avg: .253.
Carolina Panthers: Keys to the Game vs. the Arizona Cardinals
The Panthers were winless (0-4) when sacking the QB 3 or more times last season — worst in NFL; League Avg: .650.
The Panthers were 1-13 (.071) when the opposing team commits less than 60 yards in penalties last season — worst in NFL; League Avg: .495.
The Panthers are 2-6 (.250) when rushing more than 30 times since the 2023 season — worst in NFL; League Avg: .752.
The Panthers are 1-7 (.125) when sacking the QB 3 or more times since the 2023 season — worst in NFL; League Avg: .655.
Additional Matchup Notes for Arizona Cardinals vs. Carolina Panthers
The Panthers have been successful on just 28.6% of plays they have run against a stacked front this season — 2nd-worst in NFL. The Cardinals have allowed their opponents to be successful on just 33.3% of plays with a stacked front this season — T-4th-best in NFL.
The Panthers have been successful on just 37.9% of plays they have run against a stacked front since the 2023 season — 5th-worst in NFL. The Cardinals have allowed their opponents to be successful on just 37.6% of plays with a stacked front since the 2023 season — best in NFL.
Panthers TEs have 108 receptions in 31 games (just 3.5 per game) since the 2023 season — 4th-worst in NFL. The Cardinals have allowed just 4.4 receptions per game to TEs since the 2023 season — 5th-best in NFL.
The Cardinals have a third down conversion rate of just 11.7% on 3rd and 10+ YTG since the 2023 season — 3rd-worst in NFL. The Panthers defense has allowed a third down conversion rate of just 13.0% on 3rd and 10+ YTG since the 2023 season — 4th-best in NFL.
The Cardinals have gone three and out on 16.2% of their drives this season — 5th-best in NFL. The Panthers have forced three and outs on 16.8% of opponent drives this season — 5th-worst in NFL.
The Cardinals have run successful plays on just 34.4% of pass attempts against a heavy rush this season — 5th-worst in NFL. The Panthers have allowed successful plays on just 20.0% of pass attempts with a heavy rush this season — best in NFL.
Arizona Cardinals Offense: Important Stats
The Cardinals had 23 rushes of 20+ yards last season — most in NFL.
The Cardinals went for two on 36% of PATs last season — highest in NFL; League Avg: 10%.
The Cardinals have run successful plays on 32% of pass attempts against a heavy rush since the 2023 season — 2nd-worst in NFL; League Avg: 45%.
The Cardinals ran successful plays on 75% of rush attempts against a base rush last season — best in NFL; League Avg: 57%.
Carolina Panthers Offense: Important Stats
The Panthers have averaged -0.32 epa per play on play action passes this season — 2nd-worst in NFL; League Avg: 0.08.
The Panthers have averaged -0.27 epa per play on play action passes since the 2023 season — worst in NFL; League Avg: 0.08.
The Panthers scored on 50% of their drives in close and late situations last season — best in NFL; League Avg: 17%.
The Panthers have averaged 0.17 epa per play against open coverage since the 2023 season — worst in NFL; League Avg: 0.38.
Arizona Cardinals Defense: Important Stats
The Cardinals defense has allowed successful plays on 59% of pass attempts from their own territory this season — worst in NFL; League Avg: 48%.
19% of the plays ran against the Cardinals were in the red zone last season — worst in NFL; League Avg: 14%.
The Cardinals defense allowed successful plays on 49% of plays with a base front last season — worst in NFL; League Avg: 42%.
The Cardinals defense has allowed successful plays on 63% of pass attempts in the 1st quarter this season — worst in NFL; League Avg: 47%.
Carolina Panthers Defense: Important Stats
The Panthers defense has allowed an average of 2.4 yards after contact per carry (939 carries) since the 2023 season — worst in NFL; League Avg: 1.9.
The Panthers defense has allowed a passer rating of just 33.3 with a heavy rush (20 Pass Attempts) this season — best in NFL; League Avg: 105.0.
The Panthers defense has allowed 174.6 rushing yards per game (2,445/14) this season — worst in NFL; League Avg: 119.9.
The Panthers defense has allowed successful plays on 20% of pass attempts with a heavy rush this season — best in NFL; League Avg: 45%.
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More NFL Betting Predictions:
- Anytime & First Touchdown Scorer Predictions
- Receiving Yards Prop Predictions
- Rushing Yards Prop Predictions
- Passing Yards Prop Predictions
- Receptions Made Prop Predictions
- Rushing Attempts Prop Predictions
- Passing Touchdowns Prop Predictions
- QB Interception Prop Predictions
- Field Goals Made Prop Predictions
- NFL Betting Previews: Every Game
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